By the 2330s, the fleet had moved from the Romulan Neutral Zone to the Federation's spinward, coreward border. In this decade the fleet was involved the conflict with the Tzenkethi Coalition. Following the conclusion of the conflict it was based out of Starbase 621 near the Tzenkethi border.
The Fifth was heavily involved in the Federation-Cardassian War. In the early parts of the conflict it provided several tactical wings to support the Starfleet forces engaging the Cardassians. In the 2350s its operational zone was extended to include part of the Federation-Cardassian border and it moved its headquarters from Starbase 621 to be closer to the Cardassian theatre.
- 3rd Tactical Wing
- 59th Tactical Wing
- 198th Tactical Wing
- 268th Tactical Wing
- 447th Tactical Wing
Other notable ships
|United Federation of Planets fleets and task forces|
|2nd • 5th • 7th • 11th • 14th • 17th • 20th